Read e-book online Acute Leukemias: Pharmacokinetics and Management of Relapsed PDF

By A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)

ISBN-10: 3540539492

ISBN-13: 9783540539490

ISBN-10: 3642765912

ISBN-13: 9783642765919

This can be the 3rd quantity during this sequence on tools of treating acute leukemia. a number of drug resistance is mentioned, besides using human granulocyte-macrophage CSF, the position of stem telephone issue, and simple features of mobilephone biology and pharmakokinetics. there's additionally a finished part facing relapse remedy and postremission treatment. The e-book hence presents the clinician with guidance to be used in daily perform.

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Additional info for Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease

Sample text

Introduction Tumor-cell resistance to cytotoxic drugs is thought to be a major cause of failure in the chemotherapy of malignant tumors. One type identified as multi drug resistance (MDR) in experimental systems including human tumor cell lines was first described in 1970 in Chinese hamster lung and P388 leukemia cells [1]. Resistant tumor cells exhibit decreased sensitivity, not only to the initial drug used to promote resistance but also to a variety of structurally diverse molecules to which they have not been previously exposed (reviewed in [21]).

Recent studies using various molecular techniques and immunocytochemical methods have indicated that several untreated I Department of Hematology/Oncology, Klinikum Steglitz, Berlin, FRG 2 Department of Internal Medicine, University Hospital R. Virchow, Berlin, FRG 3 Medical Laser Center, LUbeck, FRG 4 Department of Pediatrics, Hannover Medical School, Hannover, FRG * Supported in part by Deutsche Krebshilfe e. V. and Deutsche Leukamie-Forschungshilfe. human cancers including hematologic malignancies are associated with increased expression of the MDRI gene, suggesting that P-gp may be responsible for intrinsic drug resistance [3, 4].

Ito Y, Tanimoto M, Kumazawa T, Okumura M, Morishima Y, Ohno R, Saito H (1989) Increased P-glycoprotein expression and multidrug-resistant gene (mdrl) amplification are infrequently found in fresh acute leukemia cells. Cancer 63: 1534-1538 7. Rothenberg ML, Mickley LA, Cole DE, Balis FM, Tsuruo T, Poplack DG, Fojo AT (1989) Expression of the mdr-lIP-170 gene in patients with acute lymphoblastic leukemia. Blood 74: 1388-1395 8. Vbezio P, Limonta M, D'Incalci M, Damia G, Masera G, Giudici G, Wolverton JS, Beck WT (1989) Failure to detect the P-glycoprotein multidrug resistant phenotype in cases of resistant childhood acute lymphocytic leukaemia.

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Acute Leukemias: Pharmacokinetics and Management of Relapsed and Refractory Disease by A. F. List, C. M. Spier, W. S. Dalton (auth.), Prof. Dr. W. Hiddemann, Prof. Dr. T. Büchner, Priv. Doz. Dr. B. Wörmann, Prof. Dr. W. Plunkett, Prof. Dr. M. Keating, Prof. Dr. M. Andreeff (eds.)


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