By Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)
Building at the current titles within the "Airways delicate Muscle" sub-series, the 6th quantity explores physiological and pharmacological tactics within the lung in vivo. some of the animal types to be had for learning the bronchospasm and irritation linked to human bronchial asthma are completely reviewed by means of the world over recognized scientists. particular chapters concentrate on the issues of administering medicines to animal airlines, the mechanics of assessing lung functionality within the versions, and describe intimately the species used, from rodents to primates. using genetically altered animals, a space of specific curiosity to molecular biologists, can be thought of intensive. This up to date and largely referenced paintings will turn out helpful to pharmacologists, physiologists and different organic scientists in any respect degrees in academia and within the pharmaceutical industry.
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Additional info for Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo
Rogers DF. Influence of Respiratory Tract Fluid on Airway Calibre. In: Raeburn D, Giembycz MA, editors. Airways Smooth Muscle: Development and Regulation of Contractility. Basel: Birkhaüser, 1994: 291-305. 68. Kapanci Y, Assimacopoulos A, Irle C, Zwahlen A, Gabbiani G. Contractile interstitial cells in pulmonary alveolar septa: A possible regulator of ventilation/perfusion ratio. J Cell Biol 1974; 60: 375-92. 69. Miller WS. The musculature of the finer divisions of the bronchial tree and its relation to certain pathological conditions.
42. Lees IW, Payne AN. Adaption and use of an ultrasonic nebulizer for inhalational studies in laboratory animals. Br J Pharmacol 1986; 87: 225P. 43. Payne AN, de Nucci G. Anaphylaxis in guinea pigs induced by ovalbumin aerosol. In vivo and in vitro methods. J Pharmacol Methods 1986; 17: 83-90. 44. Chauveau M, Leroy M, Le Gall G, Lockhart A. Bronchial provocation tests in small animals: a quantified and automated approach. J Appl Physiol 1992; 73: 410-9. 45. EideIman DH, Bellofiore S, Martin JG.
Each of these needs to be considered when designing and using animal models to evaluate the effects of drugs delivered to the airways, particularly if results are to be extrapolated to the human situation. 6. 1. Characteristics 0/ Aerosols The physical and chemical characteristics of an aerosol wh ich affect deposition include particle size, electrostatic charge and hygroscopicity. 40 s. L. Underwood and D. Raeburn A B Figure 7. Distribution of water-soluble (Evan's blue, panel A) and insoluble (oil blue N, panel B) dyes through the tracheobronchial tree of guinea pigs following administration as dry powder formulations.
Airways Smooth Muscle: Modelling the Asthmatic Response In Vivo by Steve Webber, Jan-Anders Karlsson (auth.), Dr. David Raeburn, Dr. Mark A. Giembycz (eds.)