By Richard V Heinzelman
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Additional resources for Annual reports in medicinal chemistry. / Volume 8
I - CNS Agents Engelhardt , Ed. 1 mg/kg. It was suggested that thymoxamine depresses fusimotor activity as a result of action at nor-adrenergic receptors in the spinal cord. xHaO mechanism of skeletal muscle. ~',~~ Side effects were minimal and included drowsiness, weakness, and "drunk" feelings. Most of these effects disappeared during the first week of treatment. cj*o - While drug treatment of spasticity remains a difficult problem, this report indicates several new, interesting and promising approaches to the development of more effective muscle relaxants.
A. Babulova, P. C o t i l l o , A. Bonaccorsi, I. Podvolova, J , Phrfn. , 24, 886 (1972). 23. C. K. N. Dhawan, Arch. I n t . Pharmcodyn. , 320 (1970). 24. J. Jonsson, J . Pharm. , 24, 821 (1972). 25. J. B. J. P. Buckley, J. P h a m c o l . Exp. , 180, 110 (1972). 26. J. O. Rutlsdge, J. Pharnucol. Exp. , 180, 118 (1972). 27. E. Costa, A. Gmppetti, A. Revuelta, B r i t . J. , 4l, 57 (1971). 28. H. C. T. W. Ward, J . Pharm. , 23, 468 (1971). 29. R. Samanin, D. Ghezzi, L. V a l z e l l i , S. G a r a t t i n i , Eur.
F u l l e r , J . Pham. , 171 (1972). F. Liebouitz, Proc. Nat. Acad. Sci. USA, 76, 1063 (1970). A. W. F. H. , 11, 661 (1972). 64 65 4 R. J. Schildkraut, Amer. J. , 129, 263 (1972). T. H i l l , Abstr. , Feb. 1972, p. 59. 66 67. L. L. Wolgin, Physiol. , 1,221 (1971). 68. N. W. F u l l e r , C . Mateumoto, Eur. J. , g ,98 (1972). 69 N, Riva, P. E. 6 l l e r , Naunyn-Schmiedebergr Arch. Phamakol. Exp. P at h o l . , 269, 491 (1971). H. A. Salami, J. Pharm. , 24, 900 (1972). 70 71. M. D. Bewmher, Postgrad.
Annual reports in medicinal chemistry. / Volume 8 by Richard V Heinzelman