By Colin R. Howard, Howard
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Additional info for Arenaviruses (Developments in Biochemistry)
It has been suggested by Murphy et al. (1976) that Tamiami virus infection of the cotton rat may represent an intermediate step toward immunotolerance and virus persistence, and that vertical transmission may require a certain degree of acceptance of viral antigen load. Both Machupo and Latino viruses similarly represent single host-parasite relationships which have been studied closely by Webb et al. (1 975) in order toanalyse the role of immunotolerance in persistence of thevirus in nature. Experimental infection of C.
Antibody titres are then expressed as an index calculated by subtracting the logarithmic difference between the virus titre in control and experimental reactions. Weissenbacher et al. 7 are only reported as positive if similar results are obtained on at least two further neutralization tests. Inapparent infections have been shown in approximately 38 20% of laboratory workers handling known or presumptively positive specimens. , 1974). Junin virus was isolated from two wild-caught Calomys musculinus rodents a t the same time as the recovery of LCM virus from Mus musculus trapped in the same area.
In addition, maximum security laboratories exist in many countries for the handling of economically important agricultural pathogens. These offer an additional resource of containment facilities for handling human pathogens in a national emergency. Diagnosis of human arenavirus infections and other rare but highly contagious pathogens is coordinated by the World Health Organisation, Geneva, Switzerland, where appropriate advice may be sought regarding the most suitable laboratory for receiving specimens according to geographical locality.
Arenaviruses (Developments in Biochemistry) by Colin R. Howard, Howard