Basic concepts in biochemistry: A student survival guide - download pdf or read online

By Hiram Gilbert

ISBN-10: 0071356576

ISBN-13: 9780071356572

This moment variation keeps to innovatively evaluate the hardest recommendations in biochemistry for optimum comprehension in a brief time period. in contrast to traditional texts or overview books that tension memorizing evidence, easy options stresses the getting to know of primary ideas, in order that the reader actually comprehends the fabric and feels cozy employing it. Dr. Gilbert makes use of easy, jargon-free language and award-winning instructing ideas together with algorithms, mnemonics and scientific examples.

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At each replication fork there are two DNA polymerase complexes. As the double-stranded DNA is unwound, two template strands are exposed. One of the templates can be replicated in a continuous fashion by DNA polymerase since a continuous synthesis of new strands can occur in the 5Ј to 3Ј direction as the template strand is exposed. Since all growing chains must be synthesized in the 5Ј to 3Ј direction, the lagging chain must be continuously reinitiated as new template is exposed. The lagging strand is then synthesized discontinuously, in pieces that must be joined together later.

RNA polymerase needs no primer—only a template. Either of the two DNA strands can serve as the template strand.

One way to control how much of something a cell uses or makes is to control the levels of the enzymes that are required to metabolize it (Fig. 5-7). Whether or not transcription happens is controlled by the binding of specific proteins to the DNA. When they bind to DNA, these proteins can either help or hinder the transcription process. Positive and negative refer only to the effect a protein has when it binds to the DNA. A positive effect is when the protein binds to the DNA and turns on the transcription of the gene.

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Basic concepts in biochemistry: A student survival guide by Hiram Gilbert


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